Amino Acid Metabolism
(Voet & Voet Chapter 16)
2). Nitrogen is transported to liver
either by glucose-alanine cycle or glutamine.
4). Urea is only synthesized in the liver by urea cycle enzymes (mito & cytosol).
5). Mitochondrial CPS I is the rate-limiting step of urea cycle and is allosterically activated by N-acetylglutamate.
6). How many free energy is required and produced per urea cycle?
7). What is the possible metabolic
effects of hyperammonemia in the brain?
9). Which cofactor is required for
the hydroxylation of aromatic amino acids (Phe, Tyr, Trp)? Is the cofactor
a vitamin? How is it synthesized? (Error in p. 747).
11). Epinephrine, norepinephrine, dopamine, serotonine, GABA, and histamine are hormones and/or neurotransmitters derived from amino acids. How?
12). What kind of compounds provide
unit for biosynthesis?
14). Nitrogen is only fixed by nitrogenase (Fe- and MoFe- proteins) to form NH3 in the nitrogen-fixing bacteria, diazatrophs. What is the energy reqirements?
Practice Problem : Question 2, 5, and 10, Chapter 24 (Voet & Voet p.784)
Additional Information :
fà¬§¿¯g (Phenylketonuria, PKU; Tetrahydrobiopterin Deficiency)
·¬¼ß§¿¯f¡]Maple Syrup Urine Diseas, MSUD¡^
Last modified on 1999.3.29 by K.-J. Hsiao (¿½¼s¤¯) [ º¶ ]